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Swine Flu Update Summary Page Eclipse 9-16-09
 
Tamiflu (oseltamivir)
Relenza (zanamivir)
 
Treatment with Tamiflu (oseltamivir) or Relenza (zanamivir) is recommended for persons with suspected or confirmed influenza who are at higher risk for complications: Children under 5 years old, adults 65 years and older, pregnant women, persons with certain chronic medical or immunosuppressive conditions, and persons under 19 years of age who are receiving long-term aspirin therapy.
  • Persons not at higher risk for complications do not require antiviral medications for treatment or prophylaxis. 
  • Influenza patient presenting with warning symptoms of dyspnea, tachypnea, or unexplained oxygen desaturation should promptly receive antiviral therapy. This patient should be sent to the emergency room. 
  • Treatment should be initiated as early as possible within 48 hours of illness onset. Do not wait for laboratory confirmation of influenza. 
  • Groups at higher risk for 2009 H1N1 influenza complications are similar to those at higher risk for seasonal influenza complications.
  • Providers might choose to provide patients at higher risk for influenza-related complications (patients with neuromuscular disease) with a prescription that can be filled at the onset of symptoms.
  • Antiviral chemoprophylaxis should be given to persons at higher risk for influenza-related complications who have been in contact with someone infected with influenza.
  • H1N1 influenza or seasonal influenza who present with an uncomplicated febrile illness typically do not require treatment. 
Orange County Health department stated we are in EUA, and is leaving the decision to the provider to treat children younger than 1 year or send to ER. 
  • 70% of persons hospitalized from 2009 H1N1 influenza have had a recognized high risk condition (approximately 60% of children and approximately 80% among adults).
  • Highest rates of hospitalization in children younger than 2 years of age.
  • People 65 and older are at lower risk of infection from 2009 H1N1 seasonal influenza, people 65 or older who develop 2009 H1N1 influenza infection are at increased risk of influenza-related complications.  
  • People who are obese may be at increased risk of hospitalization and death due to 2009 H1N1 influenza infection.
  • H1N1 influenza appears to be transmitted in ways similar to other influenza viruses. All respiratory secretions and bodily fluids (including diarrheal stool) should be considered potentially infectious.
Close contact is defined as a person caring for, living with a person who is a confirmed or suspected of influenza. A close contact is also a person having been in a setting where there was a high likelihood of contact with respiratory droplets and/or body fluids of a infected person. Examples of close contact include: sharing eating or drinking utensils, physical examination, or any other contact between persons likely to result in exposure to respiratory droplets. Close contact typically does not include activities such as walking by an infected person or sitting across from a symptomatic patient in a waiting room or office.
  • Aspirin or aspirin-containing products (e.g. bismuth subsalicylate – Pepto Bismol) should not be administered to any confirmed or suspected ill case of influenza. Tylenol and Motrin can be used.
  • Patients may continue to shed influenza virus for up to four or more days after beginning therapy. Continue good handwashing and respiratory practices.
Infected persons may shed influenza virus, and potentially be infectious to others, beginning one day before they develop symptoms to up to 7 days after they become ill.
Younger children can shed influenza virus for longer periods. The infectious period for influenza is one day before symptoms start until 24 hours after fever ends.
  • Antiviral agents should not be used for post exposure chemoprophylaxis in healthy children or adults based on potential exposures in the community, school, camp or other settings.
  • Chemoprophylaxis generally is not recommended if more than 48 hours have elapsed since the last contact with an infectious person. Chemoprophylaxis lowers, but does not eliminate the risk of influenza and that protection stops when the medication course is stopped. 
An emphasis on early treatment is an alternative to chemoprophylaxis after a suspected exposure for some persons. Persons with risk factors for influenza complications who are household or close contacts of confirmed or suspected cases, and health care personnel who have occupational exposures, can be counseled about the early signs and symptoms of influenza, and advised to immediately contact their health care provider for evaluation and possible early treatment if clinical signs or symptoms develop.
 
 
Pregnant Women
While Tamiflu (oseltamivir) and Relenza (zanamivir) are "Pregnancy Category C" medications, indicating that no clinical studies have been conducted to assess the safety of these medications for pregnant women, the available risk-benefit data indicate pregnant women with suspected or confirmed influenza should receive prompt antiviral therapy. Tamiflu is preferred for treatment of pregnant women. The drug of choice for chemoprophylaxis is less clear. Relenza (zanamivir) may be preferable because of its limited systemic absorption; however, respiratory complications that may be associated with Relenza (zanamivir) because of its inhaled route of administration need to be considered, especially in women at risk for respiratory problems.
 
Tamiflu (oseltamivir)  $66/5 days of treatment
  
Antiviral medication dosing recommendations for treatment or chemoprophylaxis of 2009 H1N1 infection.
(Table extracted from
IDSA guidelines for seasonal influenza.) 
 Agent, group
                                                         
 Treatment
(5 days)
 
Chemoprophylaxis
(10 days)
 
Adults
             75-mg capsule twice per day
        75-mg capsule once per day
Children ≥ 12 months
 
12mg/ml
with Syringe 30/45/60 ml
33 #
or > 1 yr
             30 mg BID
        30 mg QD
34-51 #
             45 mg BID
        45 mg QD
52-87 #
             60 mg BID
        60 mg QD
>88 #
             75 mg BID
        75 mg QD
 
Relenza (zanamivir) $72/treatment
 
Adults
Two 5-mg inhalations (10 mg total) twice per day
Two 5-mg inhalations (10 mg total) once per day
Children
Two 5-mg inhalations (10 mg total) twice per day (age, 7 years or older)
Two 5-mg inhalations (10 mg total) once per day (age, 5 years or older)
 
Tamiflu (oseltamivir)
  • Decreases the spread of influenza A and B viruses. Neuraminidase is an enzyme that enables the influenza virus to spread from infected cells to healthy cells. 
  • Reduces duration of symptoms by 1½ days if treatment is started within 48 hours after symptoms begin.
  • No generic, room temperature, prescription required.
  • Treat adults with symptoms less than 2 days. 
  • No known interactions between Tamiflu and other drugs. Tamiflu does not interact with the flu vaccine. Vaccinated individuals can use Tamiflu.
  • Tamiflu has not be evaluated in pregnant women or nursing mothers.
  • Side effects: nausea, vomiting, diarrhea, bronchitis, abdominal pain, headache and dizziness. 
  • Giving Tamiflu after meals helps reduce nausea.
Treatment and Chemoprophylaxis for Children younger than 1 Year of Age
Children younger than 1 year of age are at higher risk for influenza-related complications and have a higher rate of hospitalization compared to older children. Tamiflu is not approved for use in children younger than 1 year of age.   Limited safety data on Tamiflu treatment of seasonal influenza in children younger than 1 year of age suggest that severe adverse events are rare. Tamiflu is authorized for emergency use in children younger than 1 year of age under a EUA issued by FDA, subject to the terms and conditions of the EUA.Treatment and Chemoprophylaxis for Children younger than 1 year using Tamiflu
 
Age
Recommended treatment
dose for 5 days
Recommended prophylaxis dose for 10 days
Younger than 3 months
12 mg BID
Not recommended unless situation judged critical due to limited data on use in this age group
 
3-5 months
20 mg BID
20 mg QD
 
6-11 months
25 mg BID
25 mg QD
 
 
When using weight-based dosing for infants aged younger than 1 year for treatment, those 9 months or older should receive 3.5 mg/kg/dose BID, and those aged younger than 9 months should receive 3.0 mg/kg/dose BID.
 
Relenza (zanamivir)
  • Decreases the spread of influenza A and B viruses. Neuraminidase is an enzyme that enables the influenza virus to spread from infected cells to healthy cells. 
  • Reduces duration of symptoms by 1 day if treatment is started within 48 hours after symptoms begin.
  • No generic, room temperature, prescription required.
  • 12 years of age or older with symptoms less that 2 days.
  • Inhaler device, rotadisk containing 5 mg blisters of Relenza. Oral inhalation. 
For patients with breathing problems, if the time of administration of Relenza occurs with the use of inhaled bronchodilators, the bronchodilator should be used first. Patients with respiratory diseases may experience breathing problems when treated with Relenza due to irritation of the breathing tubes by the particles from the inhaler. If breathing problems occur, Relenza should be discontinued. Patients who have asthma or other breathing problems that make them sensitive to inhaled particles should have a fast acting, inhaled bronchodilator available to treat any breathing problem that may occur when Relenza is used. Inhaler with spacer or nebulizer increases reaction and coughing spasmatic attack.
  • No known interactions between Relenza and other drugs. Relenza does not interact with the flu vaccine. Vaccinated individuals can use Relenza. 
  • Relenza has not be evaluated in pregnant women or nursing mothers. 
  • The side effects include headaches, diarrhea, nausea, cough, vomitting and dizziness. Sinusitis, ear, nose and throat infections may occur.
Handling of Swine Flu
  • Symptoms: fever, cough, sore throat, body aches, headache, chills, fatigue, diarrhea, vomiting
  • Severe disease with pneumonia, respiratory failure or death is possible.
  • Bacterial infections may occur at the same time as after infection with influenza virus and can lead to pneumonia, ear infection or sinusitis.
Spreading of Swine Flu
Respiratory droplets spread by coughs and sneezes from person to person. These droplets are deposited in the mouth and nose of nearby people. Droplets spread infection when a person touches an object and then touches their own mouth or nose. 
 
Things to Remember with Swine Flu
  • Check with health care provider if: health condition as diabetes, heart disease, asthma or emphysema.
  • Adults stay at home 7 days after the start of illness and fever is gone. Children ususally about 10 days after the onset of symptoms.
  • A sick person should wear a surgical mask if they need to be in a common area of the house, or near other people.
  • Sick people should use separate bathroom if possible. Clean it daily with household disinfectant. Spray house areas. Wipe down counters or areas where droplets could fall and clean with disinfectant spray.
  • Use paper towels for drying hands after handwashing or dedicated towel to each person in the household.
  • Good ventilation in household areas. Keep windows open during the day.
  • Linens, eating utensils and dishes belonging to the sick person should not be shared. 
  • Wash linens (bed sheets and towels) by using laundry soap and tumble dry on a hot setting. 
  • Avoid hugging laundry prior to washing it to prevent contaminating yourself. 
  • Wash hands with soap and water right after handling dirty laundry.
  • Get rest.
  • Drink clear liquids to keep from being dehydrated.
  • Cover coughs and sneezes. Clean hands with soap and water or alcohol-based hand rub often and especially after using tissues and after coughing or sneezing into hands.
  • Avoid close contact with others-do not go to work or school while ill.
  • Do not give aspirin (acetylsalicylic acid) or Pepto Bismol for children or teenagers who have the flu, because they may get a rare illness called Reye’s Syndrome.
  • OK to take Tylenol (acetaminophen) and Ibuprofen (Advil or Motrin) for symptom relief.
  • Cool mist humdifier.
  • Use a suction bulb with saline to help clear away nasal mucus.
Seek emergency medical care if:
  • Difficulty breathing or chest pain
  • Purple or blue discoloration of the lips
  • Vomiting and unable to keep liquids down
  • Signs of dehydration, dizziness when standing
  • Seizures
  • Less responsive than normal or becomes confused
Steps to lessen spread of flu in the home
  • Keep the person away from other people as much as possible.
  • Cover coughs and sneenzes and wash hands afterwards.
If you are the caregiver:
  • Avoid being face to face with sick person (less than 6 feet away).
  • When holding small children, put their chin on your shoulder so they will not cough in your face.
  • Clean hands with soap and water, alcohol-based hand rub after you touch the sick person or handle used tissues or laundry.
  • Caregiver should wear mask around sick person.

This is a compilation  of excerpts from the www.CDC.gov website with editing by Eclipse Medical Group.  Use by members of Children's Healthcare is permitted.  Authentication of content is the responsibility of the user.